AOD 9604

AOD 9604 is a modified peptide initially developed as an offshoot in obesity research. It modifies the peptide Fragment 176-191 of the growth hormone hGH by adding a tyrosine residue to the N-terminus. The proposed mode of action of AOD 9604 has been suggested by researchers to be restricted to promoting lipolysis, thus linking the synthetic compound to obesity research.[1] The peptide does not appear to affect levels of insulin or IGF1 in studies thus far; therefore, it does not appear to trigger diabetes development or induce glucose intolerance in test models, though further studies are necessary to explore this aspect.[2]

– Specifications

• Other Known Titles: AOD-9604
• Molecular Formula: C78H123N23O23S2
• Molecular Weight: 1815.1 g/mol
• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• AOD 9604 Research
• AOD 9604 Structure

Scientists hypothesize that different parts of the hGH molecule may possess different properties and induce different effects in test models. [3] It has been suggested that only the last 15 amino acids may mediate any fat-burning potential of the hormone. The fragment was initially named hGH 177-191 and was subsequently modified by adding tyrosine to create AOD 9401, potentially to help stabilize the molecule. This modification led to the production of a 16-amino acid fragment called AOD 9604.[4] Interestingly, the researchers comment, “AOD 9604 does not interact with the hGH receptor.” This modification may have made the hGH Fragment 176-191 relatively more stable than other peptides.